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Abstract Decades of ambidexterity research have gained huge scholarly attention from diverse research areas like marketing, organizational learning, innovation management, supply chain management, strategy, and entrepreneurship. However, it has been observed that past studies do not provide a quantitative assessment of ambidexterity determinants applicable to small and medium firms. In response, this study attempts to address this gap by providing an extensive list of eight determinants that are significantly related to Small and Medium Enterprise (SME) ambidexterity. We employed Random effects meta-analytical procedure to examine the combined effect sizes of each determinant. The analysis was based on 37 empirical publications from 2004 to 2021, involving 8422 SME observations and 48 correlations. The findings of the meta-analysis revealed that all the considered determinants such as Knowledge management, Entrepreneurial orientation, Formalization, Market orientation, Networking, Technological capability, Organization context, and Environmental dynamism are heterogeneous, and they all exert a significant positive impact on ambidexterity.
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