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Today, a competitive, uncertain, and fast-changing environment requires knowledge management. In this globalized world, the health sector can offer knowledge management in addition to human and physical resources. Knowledge management gathers experience, knowledge, and expertise; develops new skills; delivers job quality; fosters innovation, and improves the customer experience. Hence, this study examined the mediating effect of knowledge management on human resource management (HRM) practices on employees’ performance in the Qatari Hospitals. Out of 500 self-administered questionnaires distributed among employees, only 315 were valid for analysis. Moreover, the data were analyzed using the Partial Least Square Structural Equational Modelling (PLS-SEM) to test the research hypotheses of this study. The findings of the study indicate that (HRM) practices and knowledge management have a significant influence on employees’ performance in the Qatari Hospitals. Also, knowledge management has had a major impact on employees’ performance in the Qatari Hospitals. Finally, knowledge management mediated the effect of HRM practices on employees’ performance in the Qatari Hospitals. The performance of this study will be a policy dialogue between the department of human resources, regulators, researchers, and policy makers. The scientific novelty of this study lies in the examination of the mediating role of knowledge management between HRM practices and employee performance in the healthcare sector. Keywords: employees’ performance, HRM practices, knowledge management, partial least square structural equational modelling, Qatari hospitals. https://doi.org/10.55463/issn.1674-2974.50.3.1
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