Articlegreen2023

Short Sleep and Insomnia Are Associated With Accelerated Epigenetic Age

Cynthia Kusters · Eric T. Klopack · Eileen M. Crimmins · Teresa E. Seeman · Steve W. Cole · Judith Carroll

40 citations0/0 files storedPsychosomatic Medicine

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Abstract

OBJECTIVE: Short sleep and insomnia are each associated with a greater risk of age-related disease, which suggests that insufficient sleep may accelerate biological aging. We examine whether short sleep and insomnia alone or together relates to epigenetic age among older adults. METHODS: A total of 3795 men (46.3%) and women aged 56 to 100 years from the Health and Retirement Study were included. Insomnia was defined as reporting at least one insomnia symptom (difficulty falling asleep, waking up at night, or waking up too early in the morning) and feeling unrested when waking up most of the time. Those reporting <6 hours of bedtime were categorized as short sleepers. Three second- or third-generation epigenetic age acceleration clocks were derived from the 2016 Health and Retirement Study Venous Blood Study. The linear regression analysis was adjusted for age, sex, race/ethnicity, education, and obesity status. RESULTS: Insomnia and short sleep were associated with acceleration of GrimAge of 0.49 (95% confidence interval [CI] = 0.03-0.94 years; p = .04) and 1.29 (95% CI = 0.52-2.07 years; p = .002) years, respectively, as well as a faster pace of aging (DunedinPACE; 0.018 [95% CI = 0.004-0.033; p = .02] and 0.022 [95% CI = -0.004 to 0.048; p = .11]). Compared with healthy sleepers, individuals with the combination of short sleep and insomnia had an accelerated GrimAge (0.97 years; 95% CI = 0.07-1.87 years, p = .04) and a greater DunedinPACE (0.032; 95% CI = 0.003-0.060, p = .04). CONCLUSIONS: Our findings indicate that short sleep, insomnia, and the combination of the two are linked to epigenetic age acceleration, suggesting that these individuals have an older biological age that may contribute to risk of comorbidity and mortality.

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References

2013Diagnostic and Statistical Manual of Mental Disorders 2002Epidemiology of insomnia: what we know and what we still need to learn 2014Cohort Profile: the Health and Retirement Study (HRS)2010Sleep Duration and All-Cause Mortality: A Systematic Review and Meta-Analysis of Prospective Studies 2015Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation 2006Psychological And Behavioral Treatment Of Insomnia: Update Of The Recent Evidence (1998–2004)2006Epidemiology of insomnia: Prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors 2004Derivation of Research Diagnostic Criteria for Insomnia: Report of an American Academy of Sleep Medicine Work Group

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