Abstract This paper aimed to explore the emerging university function of collaboration and leadership in developing large-scale research infrastructure (LRI). A qualitative approach, drawing from both primary and secondary data, was employed to delve deeper into the roles and aspects of the entrepreneurial university pertinent to LRI development. The study highlighted the need for the entrepreneurial university to establish a strategic direction for collaboration and leadership in LRIs. A conceptual model was crafted that delineated the central role of the entrepreneurial university, segmenting the findings into three research elements: (1) research and education (2) collaboration, and (3) utilization and impact. Actor perspectives from both academia and industry were included. The findings emphasized that entrepreneurial universities had to engage more robustly with external actors to foster practical research applications. Universities were found to require a more synergistic role. The model proposed that entrepreneurial universities should classify actors not only by their viewpoint but also by their potential role in LRI. Key actors were identified as belonging to LRI and multi-academic environments, with some being directly involved, while others were indirectly or peripherally engaged. Directly involved actors, including numerous academic and industrial users, had a clear understanding of LRI utility and engagement, whereas indirectly involved ones were curious yet unsure about LRI interaction.
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