NAT yield in blood donors: An observational study

Ankit Sharma · Sunita Bundas · Rashmi Parashar

4 citations0/0 files storedJournal of Family Medicine and Primary Care

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Blood donation and transfusion practices Hepatitis B Virus Studies Hepatitis C virus research

Abstract

Introduction: Individual donation nucleic acid testing (ID-NAT) is considered as highly sensitive technology for viral transfusion-transmissible infections (TTIs) in blood donors. The present study was aimed to analyze the results of ID-NAT with special reference to different types of donors, their age, gender, blood group ranges in a tertiary care center in north India. Methodology: The present study was done from 24th June 2019 to 31st December 2021 in Blood Center, Department of Immunohematology and Blood Transfusion, SMS Hospital, Jaipur. A total of 18313 apparently healthy adult donors were included in present study. Result: In 2019 Combined NAT yield was 1 in 754, in 2020 it was 1 in 2368 and in 2021 it was 1 in 741. With Total NAT yield was 1 in 1017 (0.09 %) over a period of study. NAT yield in HBV is 1 in 1077, in HCV 1 in 18313 and no NAT Yield in HIV. Conclusion: NAT testing for hepatitis B provides additional safety because ELISA does not pick up occult hepatitis. The non-seroconverting or delayed seroconverting disease is missed by ELISA alone and can be picked up by NAT.

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References

2010Refinement of a viral transmission risk model for blood donations in seroconversion window phase screened by nucleic acid testing in different pool sizes and repeat test algorithms 2015Seroprevalence of infectious markers & their trends in blood donors in a hospital based blood bank in north India 2013Nucleic acid testing for blood banks: An experience from a tertiary care centre in New Delhi, India 2012Need for Nucleic Acid Testing in Countries with High Prevalence of Transfusion-Transmitted Infections 2013Individual donor nucleic acid testing for blood safety against HIV-1 and hepatitis B and C viruses in a tertiary care hospital.2017Nucleic acid amplification testing in Indian blood banks: A review with perspectives 2017Sensitivity and specificity of a new automated system for the detection of hepatitis B virus, hepatitis C virus, and human immunodeficiency virus nucleic acid in blood and plasma donations 2015Automated nucleic acid amplification testing in blood banks: An additional layer of blood safety

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