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Innovation systems consist of different organisations from the quadruple helix, as well as the interactions and linkages between them. Smart technologies and ICT play a key role in the efficiency of systems. At the same time, regional scale is considered crucial for studying innovation in systems. However, the lack of many important data at the regional level compounds the efforts to study them. The paper proposes a novel methodological approach to the regionalisation of national-level indicators in order to address this issue. This is based on the model fit approach, using regressions to “regionalise” national-level indicators based on similar indicators that are available. The approach is tested on the data for Greek NUTS 2 regions and produces regional-level estimates for four innovation indicators, based on four available indicators that are found to be strongly correlated to them. However, the same approach can be used for any EU country or the whole of the EU. The results, their prospects for future research, and potential applications are considered. Overall, the availability of regional-level indicators is considered crucial for the formulation of impactful development policies.
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