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Sleep disorders in Parkinson’s disease, an early and multiple problem

Pauline Dodet · Marion Houot · Smaranda Leu‐Semenescu · Jean‐Christophe Corvol · Stéphane Lehéricy · Graziella Mangone +3 more

88 citations0/0 files storednpj Parkinson s Disease

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Abstract

In Parkinson's disease (PD), it remains unclear whether sleep disorders including insomnia, REM sleep behavior disorder (RBD), excessive daytime sleepiness (EDS), restless legs syndrome (RLS) and sleep-disordered breathing (SDB), are isolated or combined, interact with each other and are associated with clinical factors. We sought to determine the prevalence and combinations of the main sleep disorders, and their clinical and polysomnographic associations in early stage PD. Sleep disorders were systematically diagnosed after medical interview and video-polysomnography in 162 participants with early stage PD and 58 healthy controls from the baseline of the longitudinal ICEBERG cohort. Demographic, clinical (motor, cognitive, autonomic, psychological and sensory tests), therapeutic and polysomnographic associations of sleep disorders were investigated. Sleep disorders were frequent (71%) and combined in half of the patients. The number of sleep disorders increased with disease duration and dysautonomia. Insomnia was the most common (41%), followed by definite RBD (25%), EDS (25%), and RLS (16%). These disorders were more frequent than in controls whereas SDB was rare, moderate and similar in both groups. In patients, insomnia (mainly difficulties maintaining sleep) was associated with female gender, shorter sleep time and RLS, but not with motor or psychological symptoms. RBD was associated with dysautonomia and advanced age, but not with motor and cognitive measures. EDS was associated with psychiatric and motor symptoms as well as the sedative effects of dopamine agonists but not with other sleep disturbances. Sleep disturbances are frequent and combined in early patients with PD. Their determinants and markers are more organic than psychological.

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References

2006The association of insomnia with anxiety disorders and depression: Exploration of the direction of risk 2013Insomnia with objective short sleep duration: The most biologically severe phenotype of the disorder 2000Prevalence of insomnia in a survey of 12 778 adults in France 1987Rapid eye movement sleep behavior disorder. A treatable parasomnia affecting older adults 1988Daytime Alertness in Patients with Chronic Insomnia Compared with Asymptomatic Control Subjects 1998Correlates of Daytime Sleepiness in 4578 Elderly Persons: The Cardiovascular Health Study 2006Insomnia in Parkinson's disease: frequency and progression over time 2007Prevalence and Risk Factors of Subjective Sleepiness in the General Adult Population

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