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Abstract This chapter addresses the lack of direct comparisons between entrepreneurial ecosystems (EEs) and regional innovation systems (RISs) in the literature. Both of these systems approaches highlight a favourable regional environment for business growth but they have rarely been juxtaposed by EE scholars. We first review the EE and RIS conceptual frameworks through a comparative lens and summarize their distinguishable elements. As an application of the conceptual distinctions between EEs and RISs, we examine whether the top twenty-five most innovative Chinese cities are EE-driven or RIS-driven. Using the density and performance of high-tech start-up and incumbent firms as system outcomes, we identify four types of Chinese cities: (1) strong EE and strong RIS; (2) strong EE but weak RIS; (3) weak EE but strong RIS; and (4) weak EE and weak RIS. Lastly, we conduct an in-depth case study on three distinct Chinese cities: Shenzhen (an example of strong EE and strong RIS); Shanghai (an example of strong EE and weak RIS); and Dongguan (an example of weak EE and strong RIS). We analyse the EE/RIS input factors that may drive their distinct EE versus RIS outcome patterns.
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