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The Number of Patients Lost to Follow‐Up May Exceed the Fragility Index of a Randomized Controlled Trial Without Reversing Statistical Significance: A Systematic Review and Statistical Model
16 references·0 citing·34 second hopsampled
The Number of Patients Lost to Follow‐Up May Exceed the Fragility Index of a Randomized Controlled Trial Without Reversing Statistical Significance: A Systematic Review and Statistical Model (2024)The Number of Patients Lost to Follow‐Up …The Statistical Fragility of Operative vs Nonoperative Management for Achilles Tendon Rupture: A Systematic Review of Comparative Studies (2022)The Statistical Fragility of …The fragility of statistical significance in distal femur fractures: systematic review of randomized controlled trials (2022)The fragility of statistical …Assessing the robustness of results from clinical trials and meta-analyses with the fragility index (2022)Assessing the robustness of r…Assessing and visualizing fragility of clinical results with binary outcomes in R using the fragility package (2022)Assessing and visualizing fra…The Fragility of Statistical Significance in Patellofemoral Instability Research: A Systematic Review (2021)The Fragility of Statistical …The Fragility of Statistical Significance in Cartilage Restoration of the Knee: A Systematic Review of Randomized Controlled Trials (2021)The Fragility of Statistical …The Fragility of Statistical Findings in Achilles Tendon Injury Research: A Systematic Review (2021)The Fragility of Statistical …The Fragility Index of Hip Arthroscopy Randomized Controlled Trials: A Systematic Survey (2021)The Fragility Index of Hip Ar…Causal Language in Observational Orthopaedic Research (2021)Causal Language in Observatio…The fragility of findings of randomized controlled trials in shoulder and elbow surgery (2019)The fragility of findings of …The Fragility of Statistically Significant Results in Pediatric Orthopaedic Randomized Controlled Trials as Quantified by the Fragility Index: A Systematic Review (2018)The Fragility of Statisticall…Statistical Fragility and the Role of P Values in the Sports Medicine Literature (2018)Statistical Fragility and the…AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both (2017)AMSTAR 2: a critical appraisa…The Fragility of Statistically Significant Findings From Randomized Trials in Sports Surgery: A Systematic Survey (2016)The Fragility of Statisticall…Methodology in conducting a systematic review of systematic reviews of healthcare interventions (2011)Methodology in conducting a s…Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement (2010)Preferred reporting items for…The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies (2007)Cochrane Handbook for Systematic Reviews of Interventions (2008)The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration (2009)The PRISMA 2020 statement: an updated guideline for reporting systematic reviews (2021)The PRISMA 2020 statement: an updated guideline for reporting systematic reviews (2021)Two new Later Stone Age sites from the Final Pleistocene in the Falémé Valley, eastern Senegal (2024)The cochrane database of systematic reviews (1996)Synthesizing information systems knowledge: A typology of literature reviews (2014)Summarizing systematic reviews (2015)An overview of systematic reviews on the public health consequences of social isolation and loneliness (2017)The Measurement of Observer Agreement for Categorical Data (1977)Why Most Published Research Findings Are False (2005)The Robustness of Trials That Guide Evidence-Based Orthopaedic Surgery (2018)Scoping studies: towards a methodological framework (2005)Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement (2009)Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement (2009)INTRODUCING LEVELS OF EVIDENCE TO THE JOURNAL (2003)Identifying outcome reporting bias in randomised trials on PubMed: review of publications and survey of authors (2005)100 Most Cited Articles in Orthopaedic Surgery (2010)Evolution of Reporting P Values in the Biomedical Literature, 1990-2015 (2016)Reading and Reviewing the Orthopaedic Literature: A Systematic, Evidence-based Medicine Approach (2005)RoB 2: a revised tool for assessing risk of bias in randomised trials (2019)Predictors of Increased Fragility Index Scores in Surgical Randomized Controlled Trials: An Umbrella Review (2023)The Majority of Sports Medicine and Arthroscopy‐Related Randomized Controlled Trials Reporting Nonsignificant Results Are Statistically Fragile (2023)The Cochrane Collaboration's tool for assessing risk of bias in randomised trials (2011)Redefine statistical significance (2017)The Proposal to Lower P Value Thresholds to .005 (2018)The fragility of statistical findings in distal biceps tendon repairs: a systematic review of randomized controlled trials (2023)Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement (2009)PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews (2021)Empirical assessment of fragility index based on a large database of clinical studies in the Cochrane Library (2022)The Fragility of Landmark Randomized Controlled Trials in the Plastic Surgery Literature (2024)A scoping review on metrics to quantify reproducibility: a multitude of questions leads to a multitude of metrics (2025)The Statistical Fragility of Orbital Fractures: A Systematic Review of Randomized Controlled Trials (2023)
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References

  • 2010Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement12,421 cited
  • 2017AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both10,856 cited
  • 2011Methodology in conducting a systematic review of systematic reviews of healthcare interventions1,230 cited
  • 2016The Fragility of Statistically Significant Findings From Randomized Trials in Sports Surgery: A Systematic Survey172 cited
  • 2018The Fragility of Statistically Significant Results in Pediatric Orthopaedic Randomized Controlled Trials as Quantified by the Fragility Index: A Systematic Review72 cited
  • 2018Statistical Fragility and the Role of P Values in the Sports Medicine Literature60 cited
  • 2021The Fragility of Statistical Significance in Cartilage Restoration of the Knee: A Systematic Review of Randomized Controlled Trials45 cited
  • 2021The Fragility Index of Hip Arthroscopy Randomized Controlled Trials: A Systematic Survey44 cited
  • 2022Assessing the robustness of results from clinical trials and meta-analyses with the fragility index35 cited
  • 2021The Fragility of Statistical Significance in Patellofemoral Instability Research: A Systematic Review34 cited
  • 2022The Statistical Fragility of Operative vs Nonoperative Management for Achilles Tendon Rupture: A Systematic Review of Comparative Studies32 cited
  • 2019The fragility of findings of randomized controlled trials in shoulder and elbow surgery31 cited

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  • 2021Causal Language in Observational Orthopaedic Research31 cited
  • 2022Assessing and visualizing fragility of clinical results with binary outcomes in R using the fragility package30 cited
  • 2021The Fragility of Statistical Findings in Achilles Tendon Injury Research: A Systematic Review29 cited
  • 2022The fragility of statistical significance in distal femur fractures: systematic review of randomized controlled trials27 cited
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