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BACKGROUND: Although high-quality nutrition systematic reviews (SRs) are important for clinical decision making, there remains debate on their methodological quality and reporting transparency. OBJECTIVES: The objective of this study was to assess the reliability and reproducibility of a sample of SRs produced by the Nutrition Evidence Systematic Review (NESR) team to inform the 2020-2025 Dietary Guidelines for Americans (DGAs). METHODS: We evaluated a sample of 8 SRs from the DGA dietary patterns subcommittee for methodological quality using the Assessment of Multiple Systematic Reviews 2 (AMSTAR 2) tool and for reporting transparency using the PRISMA 2020 and PRISMA literature search extension (PRISMA-S) checklists. We assessed the quality and reproducibility of the original search strategy of one selected SR using the Peer Review of Electronic Search Strategies checklist. The reporting transparency of the SR's narrative data synthesis was assessed using the Synthesis Without Meta-Analysis (SWiM) checklist. Interpretation bias was evaluated using existing spin bias classifications in systematic reviews. RESULTS: The AMSTAR 2 assessment identified critical methodological weaknesses, and all included SRs were judged to be of critically low quality. Overall, 74% of the PRISMA 2020 checklist items and 63% of the PRISMA-S checklist items were satisfactorily fulfilled. We identified several errors and inconsistencies in the search strategy and could not reproduce searches within a 10% margin of the original results. The SWiM assessment identified concerns regarding the reporting transparency of the narrative data synthesis, but the spin bias assessment revealed no evidence of interpretation bias. CONCLUSIONS: Several methodological quality and reporting concerns were identified, which could lead to reliability and reproducibility issues should a full reproduction attempt be made. However, additional research is needed to confirm the impact of these findings on conclusions statements and their generalizability across the NESR team SRs. This study was registered in the Open Science Framework (https://osf.io/ns6a9/).
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