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This paper aims to analyze the role of open innovation practices supporting organizations and local inter-organizational interactions in the digital transformation of an industrial cluster for the adoption of Industry 4.0 technologies. To do so, we conducted qualitative research based on a case study methodology using primary and secondary data to analyze the case of the Automotive Metal-Mechanic Cluster (AMMC) of the Serra Gaúcha, in the south of Brazil. The results highlight different reactions to the transformations imposed by Industry 4.0 on the various actors of the AMMC. Large companies are ahead in the movement toward digitalization by collaborating with other companies and adapting their own culture, technologies, and new competencies to the Industry 4.0 paradigm. Small and medium-sized companies (SMEs) react differently by using local support organizations (the Helix Institute) to adapt, presenting weaker network connections and more restricted technological capabilities.
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