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Purpose: elaboration of scientific and applied recommendations for the development of regional innovation ecosystems within the framework of the innovation growth paradigm actualisation. Methods: theoretical provisions of the new growth theory, the theory of complex systems, the concept of open innovation, and the ecosystem approach formed the methodological basis of the research. The methods of interdisciplinary, bibliographic, structural-logical and statistical analysis, methods of scientific generalisation and systematisation were used. Results: it is shown that in modern economic conditions a special role in enhancing the innovation process is assigned to regional innovation ecosystems that are able to ensure the continuity of the innovation cycle by strengthening the integration of participants. The analysis of the problems of innovation activity enhancement of the RF subjects has revealed a number of factors that determine the need to form a new space of interaction that corresponds to the structure and specifics of ecosystem transformation of modern economy. The priorities of levelling the organisational and functional limitations of regional innovation ecosystems development in the process of commercialization and scaling of their aggregate value proposition were formulated. The organisational model of formation and evolution of regional innovation ecosystems, including key conditions, characteristic features, potential barriers, mechanisms and tools to support their development, has been developed. Conclusions and Relevance: in the context of rapid technological progress, the demand for and implementation of the concept of regional innovation ecosystems as an effective form of enhancing innovation activity is high. To accelerate the ecosystem transformation of regional economies, it is necessary to create conditions that promote expanded cooperation, strengthen synergy and symbiosis of joint activities of complementary participants in innovation networks. It is important to achieve a systemic compromise of their goals and interests to ensure a balanced structure of subjects of innovation interaction and regional resources. The proposed organizational model can be used to structure the mechanism for the formation of innovation ecosystems, taking into account potential barriers and limitations of the ecosystem transformation of the regional innovation landscape. Prospects for further research are related to clarifying regional priorities of growth policy and mechanisms for their implementation in the ecosystem format in relation to the tasks of increasing the innovative activity of the constituent entities of the Russian Federation.
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