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Abstract Simulation modeling makes use of computational resources in fields that are not of a mathematical nature. The first part of this chapter introduces four phases of the historical development of computation and simulation (C&S) and discusses their relationship to interdisciplinarity. Starting with a pioneering phase, C&S went through disciplinary specialization, ubiquitous diffusion, and a recent infrastructural turn. The second part of the chapter explores aspects of the interdisciplinary dynamics of C&S, especially the interplay between complexity, experimentation, and visualization. Then, C&S is put in relationship to Shinn’s “research technology” and Galison’s “trading zones.” Finally, the chapter observes a recent turn toward network-like interdisciplinary integration.
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