Articlebronze2010

Association between a Serotonin Transporter Length Polymorphism and Primary Insomnia

Michael Deuschle · Michael Schredl · Cláudia Schilling · Stefan Wüst · Josef Frank · Stephanie H. Witt +4 more

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Abstract

STUDY OBJECTIVE: To test the hypothesis that a 44-base-pair insertion/deletion polymorphism in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR) is associated with primary insomnia. DESIGN: Association study. SETTING: Sleep laboratory at the Central Institute of Mental Health, Mannheim, Germany. PATIENTS: 157 patients with primary insomnia and 827 healthy controls. INTERVENTIONS: N/A. MEASUREMENT AND RESULTS: We found the short (s-) allele of the 5-HTTLPR to be significantly more frequent in patients suffering from insomnia than in control individuals (47.1% vs. 39.9%: OR = 1.34). CONCLUSIONS: This finding contributes to the understanding of the pathophysiology of primary insomnia and suggests a biological basis between the prevalent comorbidity of primary insomnia and other psychiatric disorders.

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References

2002Epidemiology of insomnia: what we know and what we still need to learn 2002Place of chronic insomnia in the course of depressive and anxiety disorders 1997Psychophysiological insomnia: the behavioural model and a neurocognitive perspective 2002Primary insomnia: a risk factor to develop depression?1981Onset of Insomnia: Role of Life-Stress Events1 2000Symptoms of Stress and Depression as Correlates of Sleep in Primary Insomnia 2002Interactions between evening and nocturnal cortisol secretion and sleep parameters in patients with severe chronic primary insomnia 1990Evidence for Genetic Influences on Sleep Disturbance and Sleep Pattern in Twins

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