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This article introduces a series of tutorials originally presented at the first annual World Association of Modeling Biologically Accurate Modeling Meeting (WAM-BAMM*05) held in the spring of 2005 in San Antonio, Texas (http://www.wam-bamm.org). This meeting was specifically designed to support and promote “realistic” biological modeling. This form of modeling, which is core to the GENESIS simulation project (http://www.genesis-sim.org/GENESIS/), is premised on the assumption that models should FIRST incorporate known anatomical and physiological features of biological systems, and THEN be used as tools to generate NEW ideas and experimental directions in exploring structure / function relationships. The meeting was attended by close to 100 participants. We were particularly pleased to have both the GENESIS and NEURON (Hines and Carnevale, 1997) modeling environments represented.
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