Article2002

The Effects of Mirtazapine on Sleep: A Placebo Controlled, Double-Blind Study in Young Healthy Volunteers

Selçuk Aslan · Erdal Işık · Behçet Çoşar

136 citations0/0 files storedSLEEP

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Abstract

STUDY OBJECTIVES: Mirtazapine is classified as a noradrenergic and specific serotonergic antidepressant. This study aims at objectively investigating the effects of single-dose mirtazapine on sleep of healthy volunteers. DESIGN AND SETTING: We studied the effect of acute administration of mirtazapine (30 mg) on the sleep polysomnogram, using a double-blind, placebo-controlled design. Subjects spent 3 consecutive nights in the laboratory. First night allowed for adaptation to the laboratory and application of electroencephalogram electrodes, while the second and third nights were reserved for recording baseline sleep and studying the effects of drug treatment, respectively. PARTICIPANTS: Young healthy volunteers (n=20), with a mean age of 24 years, were randomly separated into two groups: placebo (n=10) and mirtazapine (n=10). INTERVENTIONS: On the third night, subjects received either placebo or mirtazapine. Comparisons were made between sleep variables from baseline values in both groups. Independent samples t-test was utilized to evaluate the differences between the two groups. MEASUREMENT AND RESULTS: Mirtazapine improved the variables related to sleep continuity when compared with placebo. It increased the sleep efficiency index, while decreasing the number of awakenings and their duration. The slow wave sleep time was increased, while the stage 1 sleep time was decreased significantly. There was no significant effect on rapid eye movement sleep variables. CONCLUSION: Our findings suggest that mirtazapine has considerable effects on slow wave sleep. Further studies are recommended to investigate the efficiency of antidepressants, in respect to the effects of 5-HT2 blockade on slow wave sleep.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 136 citations exist upstream.

References

1960A RATING SCALE FOR DEPRESSION 1968A manual for standardized terminology, techniques and scoring system for sleep stages in human subjects 1987Sleep Research in Affective Illness: State of the Art Circa 1987 1998Comparative effects of nefazodone and fluoxetine on sleep in outpatients with major depressive disorder

Cited by

2005Chronic Insomnia 2011Pharmacological treatment of sleep disturbance in developmental disabilities: A review of the literature 2012Histamine-1 receptor antagonism for treatment of insomnia 2017Low doses of mirtazapine or quetiapine for transient insomnia: A randomised, double-blind, cross-over, placebo-controlled trial 2006Polysomnographic and Symptomatological Analyses of Major Depressive Disorder Patients Treated with Mirtazapine 2016Mirtazapine does not improve sleep disorders in A lzheimer's disease: results from a double‐blind, placebo‐controlled pilot study 2010Medication Effects on Sleep 2012What Is the Role of Sedating Antidepressants, Antipsychotics, and Anticonvulsants in the Management of Insomnia?

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.