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Rebuilding the R&D engine in big pharma.
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Rebuilding the R&D engine in big pharma. (2008)Rebuilding the R&D engine in big pharma.Technological mediation, mediating morality and moral imaginaries of design: Performance measurement systems in the pharmaceutical industry (2024)Technological mediation, medi…The introduction of research ethics review procedures at a university in South Africa: review outcomes of a social science research ethics committee (2020)The introduction of research …The endless frontier? The recent increase of R&D productivity in pharmaceuticals (2020)The endless frontier? 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(2012)Big Pharma, little science?A co-evolutionary perspective on the drivers of international sourcing of pharmaceutical R&D to India (2012)A co-evolutionary perspective…The impact of mergers on pharmaceutical R&D (2011)The impact of mergers on phar…Drug discovery management, small is still beautiful: Why a number of companies get it wrong (2011)Drug discovery management, sm…When R&D spending is not enough: The critical role of culture when you really want to innovate (2010)When R&D spending is not enou…The case for open‐access chemical biology (2009)The case for open‐access chem…Organizing for innovation: towards successful translational research (2009)Organizing for innovation: to…Lessons from 60 years of pharmaceutical innovation (2009)How to improve R&D productivity: the pharmaceutical industry's grand challenge (2010)Collaborative practices for medicinal chemistry research across the big pharma and not-for-profit interface (2014)Evolving Outsourcing Landscape in Pharma R&D: Different Collaborative Models and Factors To Consider When Choosing a Contract Research Organization (2020)Many are called, few are chosen: the role of science in drug development decisions (2023)Diagnosing the decline in pharmaceutical R&D efficiency (2012)Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework (2014)Measuring the effectiveness and impact of an open innovation platform (2017)Achieving end-to-end success in the clinic: Pfizer’s learnings on R&D productivity (2021)Projections of Global Mortality and Burden of Disease from 2002 to 2030 (2006)Target prices for mass production of tyrosine kinase inhibitors for global cancer treatment (2016)Systematic review and meta-analysis (2019)Financial Protection in Health among the Elderly – A Global Stocktake (2021)Expanding access to biotherapeutics in low-income and middle-income countries through public health non-exclusive voluntary intellectual property licensing: considerations, requirements, and opportunities (2022)Agendas, alternatives, and public policies (1984)Agendas, Alternatives, and Public Policies (1985)The New production of knowledge: the dynamics of science and research in contemporary societies (1995)University R&D Funding Strategies in a Changing Federal Funding Environment (2014)Delineating social finance (2020)Societal targeting in researcher funding: An exploratory approach (2021)Culture's Consequences: International Differences in Work-Related Values (1981)Increasing Returns and Long-Run Growth (1986)Organizational culture and leadership (1993)The Impact of HRM Capabilities on Innovation Mediated by Knowledge Management Capability (2013)Understanding Cultural Differences in Innovation: A Conceptual Framework and Future Research Directions (2014)How Does Material Resource Adequacy Affect Innovation Project Performance? A Meta‐Analysis (2017)Can the pharmaceutical industry reduce attrition rates? (2004)Key factors in the rising cost of new drug discovery and development (2004)Prospects for productivity (2004)Can Open-Source Drug R&D Repower Pharmaceutical Innovation? (2010)Recalibrating Intellectual Property Rights to Enhance Translational Research Collaborations (2012)Interorganizational Collaboration and the Locus of Innovation: Networks of Learning in Biotechnology (1996)Open Innovation: The New Imperative for Creating and Profiting from Technology (2003)Software survey: VOSviewer, a computer program for bibliometric mapping (2009)Research excellence and university-industry collaboration in UK science parks (2014)Effects of M&As on innovation performance: empirical evidence from Chinese listed manufacturing enterprises (2016)Analysis of pharma R&D productivity – a new perspective needed (2023)The Pricing of Options and Corporate Liabilities (1973)THE VALUATION OF RISK ASSETS AND THE SELECTION OF RISKY INVESTMENTS IN STOCK PORTFOLIOS AND CAPITAL BUDGETS**This paper is another in a series of interrelated theoretical and statistical studies of corporate financial and investment policies being made under grants from the Rockefeller Foundation, and more recently the Ford Foundation, to the Harvard Business School. The generous support for this work is most gratefully acknowledged. The author is also much indebted to his colleagues Professors Bishop, Christenson, Kahr, Raiffa, and (especially) Schlaifer, for extensive discussion and commentary on an earlier draft of this paper; but responsibility for any errors or imperfections remains strictly his own.[Professor Sharpe's paper, “Capital Asset Prices: A Theory of Market Equilibrium Under Conditions of Risk” (Journal of Finance, September 1964) appeared after this paper was in final form and on its way to the printers. My first section, which parallels the first half of his paper (with corresponding conclusions), sets the algebraic framework for sections II, III and VI, (which have no counterpart in his paper) and for section IV on the equilibrium prices of risk assets, concerning which our results differ significantly for reasons which will be explored elsewhere. Sharpe does not take up the capital budgeting problem developed in section V below.] (1975)The price of innovation: new estimates of drug development costs (2003)The Social Transformation of American Medicine (1984)Technology policy and economic performance, lessons from Japan (1988)Collective value creation: a new approach to stakeholder value (2022)From Financialisation to Innovation in UK Big Pharma (2022)Investing in Innovation (2023)Optimal Detection of Changepoints With a Linear Computational Cost (2012)Innovation in the pharmaceutical industry: New estimates of R&D costs (2016)
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  • 2020The introduction of research ethics review procedures at a university in South Africa: review outcomes of a social science research ethics committee38 cited
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Drug discovery management, small is still beautiful: Why a number of companies get it wrong
27 cited
  • 2012Individual preferences, organization, and competition in a model of R&D incentive provision25 cited
  • 2009Organizing for innovation: towards successful translational research25 cited