The health implications of low hemoglobin deferral in infrequent blood donors

Kyle Annen · Meghan Delaney · Dave Leitch · Alan E. Mast

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Blood donation and transfusion practices Iron Metabolism and Disorders Blood transfusion and management

Abstract

BACKGROUND: The causes of anemia in infrequent blood donors deferred for low hemoglobin (Hb) are not well known. We sought to assess this via surveys of infrequent, non-menstruating deferred blood donors at two institutions, BloodCenter of Wisconsin and Puget Sound Blood Center. STUDY DESIGN AND METHODS: Men at least 18 years of age and women at least 50 years of age who were deferred for low Hb (≤12.5 g/dL), had not more than one donation in the year prior to deferral, and did not successfully donate in the 3 months after their deferral were surveyed. RESULTS: The total response rate was 380 donors or 34% of those contacted. Of the respondents, 141 had sought medical advice about their low Hb. Of these, 90 were confirmed to have anemia and 13 reported serious disease requiring medical intervention, including mantle cell lymphoma, multiple myeloma, and gastrointestinal bleeding. CONCLUSIONS: A small but concerning number of infrequent blood donors deferred for low Hb have an underlying illness that is severe and would benefit from medical attention. Donors deferred for low Hb who have a high risk for serious underlying illness should be provided targeted educational information advising them to seek additional medical care.

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References

2006Iron depletion by whole‐blood donation harms menstruating females: The current whole‐blood‐collection paradigm needs to be changed 2010Donor return after temporary deferral 2010The impact of temporary deferral due to low hemoglobin: future return, time to return, and frequency of subsequent donation 2011The difference between fingerstick and venous hemoglobin and hematocrit varies by sex and iron stores 2010Blood center practice and education for blood donors with anemia 2006The blood centre as a community health resource 2009Community blood donors' knowledge of anemia and design of a literacy‐appropriate educational intervention

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