Effect of increasing hemoglobin cutoff in male donors and increasing interdonation interval in whole blood donors at a hospital‐based blood donor center

Manish J. Gandhi · Kimberly Duffy · Mary Benike · Sarah M. Jenkins · James R. Stubbs

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Blood donation and transfusion practices Blood transfusion and management Organ Donation and Transplantation

Abstract

BACKGROUND: The NHANES-III survey found hemoglobin (Hb) concentrations of more than 13.5 g/dL and more than 12.0 g/dL in normal Caucasian males and females. In the United States, a Hb of least 12.5 g/dL is required for blood donation, which allows "anemic" males to donate while excluding "normal" females. Low Hb is the major cause of deferral in donors and deferrals are associated with decreased donor return rates. Additionally, frequent blood donations are associated with depletion of body iron stores. Analysis of the effect of various Hb cutoffs and interdonation intervals on our center's blood supply is presented. STUDY DESIGN AND METHODS: Whole blood donor data for a 12-month period were studied. Potential effects on the blood supply by increasing male Hb eligibility levels and/or increasing the interdonation interval were analyzed. RESULTS: A total of 13,519 individuals (females, 56%) donated 30,678 units (mean frequency, male 2.7 and females 2.1) with the majority (42%) donating once. Increasing the male Hb eligibility to at least 13.5 g/dL will decrease collections by 1457 (5%) units. In addition, decreasing the female Hb eligibility to at least 12.0 g/dL will result in total gain of 307 (1%) units. Considering 12-week interdonation interval and Hb eligibility of at least 13.5 g/dL (male) and at least 12.5 g/dL (female) results in decrease of 11% (3352) units. CONCLUSIONS: Increasing the Hb cutoff for male donors and/or interdonation interval for all donors will decrease available blood, some of which may be reduced by decreasing the Hb cutoff for females to at least 12.0 g/dL. As a majority of the donors donate only once with mean donation frequency being 2.4, it may be possible to overcome this shortfall by targeted recruitment of donors donating once.

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References

2002Blood donors and factors impacting the blood donation decision 1998The effect of short‐term, temporary deferral on future blood donation 2008Donor deferral and resulting donor loss at the American Red Cross Blood Services, 2001 through 2006 2006Iron depletion by whole‐blood donation harms menstruating females: The current whole‐blood‐collection paradigm needs to be changed 2010Donor return after temporary deferral 2010Demographic correlates of low hemoglobin deferral among prospective whole blood donors 2010The impact of temporary deferral due to low hemoglobin: future return, time to return, and frequency of subsequent donation 2008Evidence‐based criteria for the care and selection of blood donors, with some comments on the relationship to blood supply, and emphasis on the management of donation‐induced iron depletion

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2012The aging of the donor base 2019Changes in minimum hemoglobin and interdonation interval: impact on donor hemoglobin and donation frequency 2018Donor understandings of blood and the body in relation to more frequent donation 2018Options for possible changes to the blood donation service: health economics modelling

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