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Characterization of the Pediatric Acute-Onset Neuropsychiatric Syndrome Phenotype

Tanya K. Murphy · Priyal D. Patel · Joseph F. Mcguire · Allison Kennel · P. Jane Mutch · Ellisa Carla Parker-Athill +6 more

110 citations0/0 files storedJournal of Child and Adolescent Psychopharmacology

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Obsessive-Compulsive Spectrum Disorders Streptococcal Infections and Treatments Autoimmune Neurological Disorders and Treatments

Abstract

OBJECTIVE: Pediatric acute-onset neuropsychiatric syndrome (PANS) is a subtype of obsessive compulsive disorder (OCD) marked by an abrupt onset or exacerbation of neuropsychiatric symptoms. We aim to characterize the phenotypic presentation of youth with PANS. METHODS: Forty-three youth (ages 4-14 years) meeting criteria for PANS were assessed using self-report and clinician-administered measures, medical record reviews, comprehensive clinical evaluation, and laboratory measures. RESULTS: Youth with PANS presented with an early age of OCD onset (mean=7.84 years) and exhibited moderate to severe obsessive compulsive symptoms upon evaluation. All had comorbid anxiety and emotional lability, and scored well below normative means on all quality of life subscales. Youth with elevated streptococcal antibody titers trended toward having higher OCD severity, and presented more frequently with dilated pupils relative to youth without elevated titers. A cluster analysis of core PANS symptoms revealed three distinct symptom clusters that included core characteristic PANS symptoms, streptococcal-related symptoms, and cytokine-driven/physiological symptoms. Youth with PANS who had comorbid tics were more likely to exhibit a decline in school performance, visuomotor impairment, food restriction symptoms, and handwriting deterioration, and they reported lower quality of life relative to youth without tics. CONCLUSIONS: The sudden, acute onset of neuropsychiatric symptoms, high frequency of comorbidities (i.e., anxiety, behavioral regression, depression, and suicidality), and poor quality of life capture the PANS subgroup as suddenly and severely impaired youth. Identifying clinical characteristics of youth with PANS will allow clinicians to diagnose and treat this subtype of OCD with a more strategized and effective approach.

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References

1997The Screen for Child Anxiety Related Emotional Disorders (SCARED): Scale Construction and Psychometric Characteristics 1989The Yale Global Tic Severity Scale: Initial Testing of a Clinician-Rated Scale of Tic Severity 1997Children's Yale-Brown Obsessive Compulsive Scale: Reliability and Validity 1998Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections: Clinical Description of the First 50 Cases 2011Practice Parameter for the Assessment and Treatment of Children and Adolescents With Obsessive-Compulsive Disorder 2004Psychometric evaluation of the Children's Yale–Brown Obsessive-Compulsive Scale 1995Rey complex figure test under four different administration procedures 1999Gender-related clinical differences in obsessive-compulsive disorder

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