Granulocyte Kinetics in Donors Undergoing Filtration Leukapheresis

Jonathan M. Rubins · J. L. MacPherson · Jacob Nusbacher · Tom B. Wiltbank

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Blood donation and transfusion practices Hematopoietic Stem Cell Transplantation Blood disorders and treatments

Abstract

Normal blood donors undergoing filtration leukapheresis (FL) have a profound transient neutropenia early in the procedure which is followed by a "rebound" neutrophilia. This phenomenon occurs in unstimulated donors as well as in donors pretreated with either prednisone or dexamethasone. The mechanism for development of the neutropenia was investigated in volunteers throug a nylon filter at 37 C, a significant but transient neutropenia was observed. Plasma rendered cell and stroma-free achieved the same result indicating that plasma alone, when exposed to nylon fibers, is capable of producing neutropenia.

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1977Abdominal pain in donors during filtration leukapheresis 1982Adverse Reactions to Whole Blood Donation and Plasmapheresis

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