Adverse Reactions to Whole Blood Donation and Plasmapheresis

Alfred J. Grindon

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Blood donation and transfusion practices Blood transfusion and management Ethics in Clinical Research

Abstract

Whole blood donation is recognized to be extremely safe, yet there have been reports of serious problems stemming from whole blood donation, and so-called "donor reactions" are regularly seen. While the physiologic causes of the common donor reactions are not completely understood, some effects of whole blood donation (such as transient iron deficiency) are understood but probably not significant. In order to avoid accepting any volunteer donor who might be at risk of a serious reaction, we may have been overly cautious in exclusion of potential donors. The pheresis donor is subjected to potential depletion of the protein or cellular elements being removed, problems caused by the device used for automated pheresis, or problems related to the infusion of potentially toxic substances. Documented benefit to the patient must balance these additional risks.

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References

1971Leukocyte and Platelet Collection from Normal Donors with the Continuous Flow Blood Cell Separator 1980Vasovagal Reactions in Blood Donors 1974Increased Granulocyte Collection with the Blood Cell Separator and the Addition of Etiocholanolone and Hydroxyethyl Starch 1964Effects of Intensive Plasmapheresis on Normal Blood Donors 1954Work Capacity After Blood Donation 1975Short‐Term and Long‐Term Effects of Plasmapheresis on Serum Proteins and Immunoglobulins 1963Study of the Incidence and Characteristics of Blood Donor “Reactors”1981The safety of weekly plateletpheresis: effect on the donors' lymphocyte population

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2015Donor Hemovigilance with Blood Donation 2023A donor safety evidence literature review of the short‐ and long‐term effects of plasmapheresis 2014Donor Research in Australia: Challenges and Promise 2006Hematomas in multicomponent apheresis: searching for related factors

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