Neurobiological Substrates of Tourette's Disorder

James Frederick Leckman · Michael H. Bloch · Megan E. Smith · Daouia I. Larabi · Michelle Hampson

199 citations0/0 files storedJournal of Child and Adolescent Psychopharmacology

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Obsessive-Compulsive Spectrum Disorders Neural and Behavioral Psychology Studies Neurological disorders and treatments

Abstract

OBJECTIVE: This article reviews the available scientific literature concerning the neurobiological substrates of Tourette's disorder (TD). METHODS: The electronic databases of PubMed, ScienceDirect, and PsycINFO were searched for relevant studies using relevant search terms. RESULTS: Neuropathological as well as structural and functional neuroimaging studies of TD implicate not only the sensorimotor corticostriatal circuit, but also the limbic and associative circuits as well. Preliminary evidence also points to abnormalities in the frontoparietal network that is thought to maintain adaptive online control. Evidence supporting abnormalities in dopaminergic and noradrenergic neurotransmission remains strong, although the precise mechanisms remain the subject of speculation. CONCLUSION: Structural and functional abnormalities in multiple parallel corticostriatal circuits may underlie the behavioral manifestations of TD and related neuropsychiatric disorders over the course of development. Further longitudinal research is needed to elucidate these neurobiological substrates.

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References

2005Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome 2002Tourette's syndrome 1998Course of Tic Severity in Tourette Syndrome: The First Two Decades 1993Premonitory urges in Tourette's syndrome 2005Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome 2003Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome 2005Premonitory Urge for Tics Scale (PUTS)1998A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome

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