Sequence analysis of the promoter region of the rat vasopressin gene

Evita Mohr · Dietmar Richter

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Neuroendocrine regulation and behavior Genomics and Chromatin Dynamics Neuropeptides and Animal Physiology

Abstract

The vasopressin gene is highly transcribed in magnocellular neurons of the supraoptic (SON) and paraventricular nucleus (PVN) in the rat hypothalamus. In order to identify cis-acting elements involved in the expression of the vasopressin gene, approximately 1 kb upstream of the transcription start site has been sequenced. Several putative regulatory elements have been detected, including a glucocorticoid response element (CRE), a cAMP response element (CRE), and four AP2 binding sites. In gel shift assays performed with a labelled DNA fragment corresponding to nucleotide residues -214 to -36 and nuclear proteins extracted from SON-derived tissue enriched in magnocellular neurons, three specific protein-DNA complexes have been detected. Complex formation is effectively competed by addition of an excess of unlabelled fragment.

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References

1982TECHNOLOGICAL EXAMINATION OF LOW‐FIRED TERRACOTTA STATUES FROM AYIA IRINI, KEA 1985The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line.1975DISTRIBUTION OF OXYTOCIN AND VASOPRESSIN IN THE RAT SUPRAOPTIC AND PARAVENTRICULAR NUCLEUS 2008Differential Responses to Osmotic Stress of Vasopressin-Neurophysin mRNA in Hypothalamic Nuclei 1988Oxytocin and vasopressin gene expression during gestation and lactation 1987Oxytocin Gene Expression in Discrete Hypothalamic Magnocellular Cell Groups Is Stimulated by Prolonged Salt Loading 1988Expression of the vasopressin and oxytocin genes in rats occurs in mutually exclusive sets of hypothalamic neurons 1986The Neurohypophyseal Hormones Vasopressin and Oxytocin. Precursor Structure, Synthesis and Regulation

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1999Evidence for Conservation of the Vasopressin/Oxytocin Superfamily in Annelida 2011Cell‐Type Specific Expression of Oxytocin and Vasopressin Genes: An Experimental Odyssey 1994Proto-oncogene c-fos and the regulation of vasopressin gene expression during dehydration

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