DCDC2 genetic variants and susceptibility to developmental dyslexia

Cecilia Marino · Haiying Meng · Sara Mascheretti · Marianna Rusconi · Natalie A. Cope · Roberto Giorda +2 more

80 citations0/0 files storedPsychiatric Genetics

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Reading and Literacy Development Language Development and Disorders Genetic Associations and Epidemiology

Abstract

OBJECTIVE(S): Developmental dyslexia is a heritable condition, with genetic factors accounting for 44-75% of the variance in performance tests of reading component subphenotypes. Compelling genetic linkage and association evidence supports a quantitative trait locus in the 6p21.3 region that encodes a gene called DCDC2. In this study, we explored the contribution of two DCDC2 markers to dyslexia, related reading and memory phenotypes in nuclear families of Italian origin. METHODS: The 303 nuclear families recruited on the basis of having a proband with developmental dyslexia have been studied with 6p21.3 markers, BV677278 and rs793862. Marker-trait association was investigated by the quantitative transmission disequilibrium test (version 2.5.1) that allows for the analyses of quantitative traits. Seven phenotypes were used in association analyses, that is, word and nonword reading, word and nonword spelling, orthographic choice, memory, and the affected status based on inclusion criteria. RESULTS: Quantitative transmission disequilibrium test analyses yielded evidence for association between reading skills and the BV677278 deletion (empirical P-values=0.025-0.029) and between memory and BV677278 allele 10 (empirical P-value=0.0001). CONCLUSION: Our result adds further evidence in support of DCDC2 contributing to the deficits in developmental dyslexia. More specifically, our data support the view that DCDC2 influences both reading and memory impairments thus shedding further light into the etiologic basis and the phenotypic complexity of developmental dyslexia.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 80 citations exist upstream.

References

2004Specific reading disability (dyslexia): what have we learned in the past four decades?2005Working memory in children with reading disabilities 2005Generalist Genes and Learning Disabilities.1994Quantitative Trait Locus for Reading Disability on Chromosome 6 1997Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15.2009Working Memory, Short-Term Memory, and Reading Disabilities 2005DCDC2 is associated with reading disability and modulates neuronal development in the brain 2005Strong Evidence That KIAA0319 on Chromosome 6p Is a Susceptibility Gene for Developmental Dyslexia

Cited by

2014The correlation between reading and mathematics ability at age twelve has a substantial genetic component 2014The DCDC2 Intron 2 Deletion Impairs Illusory Motion Perception Unveiling the Selective Role of Magnocellular-Dorsal Stream in Reading (Dis)ability 2012An assessment of gene‐by‐environment interactions in developmental dyslexia‐related phenotypes 2013The Genetics of Reading Disabilities: From Phenotypes to Candidate Genes 2013

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.