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Antonello may have emulated more than just the style and technique of Flemish art, for in the Jerome, he created a complex iconographical program in the manner of Van Eyck. This analysis suggests that Jerome's Epistle 22, advising Eustochium to become a penitential recluse, is the source for the imagery. Themes include the sinful city and the paradisiacal wilderness, the Wise and Foolish Virgins, and the contemplative life. Further, an explanation is offered for the many references to the Virgin: Jerome, like Mary, produced the Word in physical form and was considered a source of cleansing and nourishment for mankind.
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