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Statistically significant meta-analyses of clinical trials have modest credibility and inflated effects
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Statistically significant meta-analyses of clinical trials have modest credibility and inflated effects (2011)Statistically significant meta-analyses o…Stopping Randomized Trials Early for Benefit and Estimation of Treatment Effects Systematic Review and Meta-regression Analysis (2010)Stopping Randomized Trials Ea…Why Most Discovered True Associations Are Inflated (2008)Why Most Discovered True Asso…Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation (2008)Sensitivity of between-study …Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study (2008)Empirical evidence of bias in…Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses? (2008)Can trial sequential monitori…Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis (2007)Trial sequential analysis may…Epidemiology and Reporting Characteristics of Systematic Reviews (2007)Epidemiology and Reporting Ch…Why Most Published Research Findings Are False (2005)Why Most Published Research F…Contradicted and Initially Stronger Effects in Highly Cited Clinical Research (2005)Contradicted and Initially St…Reported Methodologic Quality and Discrepancies between Large and Small Randomized Trials in Meta-Analyses (2001)Reported Methodologic Quality…Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement (1999)Improving the quality of repo…Effect of the Statistical Significance of Results on the Time to Completion and Publication of Randomized Efficacy Trials (1998)Effect of the Statistical Sig…Quantitative Synthesis in Systematic Reviews (1997)Quantitative Synthesis in Sys…Discrepancies between Meta-Analyses and Subsequent Large Randomized, Controlled Trials (1997)Discrepancies between Meta-An…Meta-Analyses of Randomized Controlled Trials (1987)Meta-Analyses of Randomized C…Meta-analysis in clinical trials (1986)Meta-analysis in clinical tri…Exploratory Research (2020)Exploratory ResearchEstimating publication bias in meta‐analyses of peer‐reviewed studies: A meta‐meta‐analysis across disciplines and journal tiers (2020)Estimating publication bias i…Statistical power of clinical trials increased while effect size remained stable: an empirical analysis of 136,212 clinical trials between 1975 and 2014 (2018)Statistical power of clinical…Raising Awareness for the Replication Crisis in Clinical Psychology by Focusing on Inconsistencies in Psychotherapy Research: How Much Can We Rely on Published Findings from Efficacy Trials? (2018)Raising Awareness for the Rep…Are Meta-Analyses a Form of Medical Fake News? (2017)Are Meta-Analyses a Form of M…Poor agreement in significant findings between meta-analyses and subsequent large randomized trials in perioperative medicine (2016)Poor agreement in significant…Can systematic reviews with sparse data be trusted? (2016)Can systematic reviews with s…When may systematic reviews and meta-analyses be considered reliable? (2015)When may systematic reviews a…Systematic Reviews of Anesthesiologic Interventions Reported as Statistically Significant (2015)Systematic Reviews of Anesthe…Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies (2015)Statistical and Methodologica…Accumulating Research: A Systematic Account of How Cumulative Meta-Analyses Would Have Provided Knowledge, Improved Health, Reduced Harm and Saved Resources (2014)Accumulating Research: A Syst…A Call for Examining Replication and Bias in Special Education Research (2014)A Call for Examining Replicat…Comparative effect sizes in randomised trials from less developed and more developed countries: meta-epidemiological assessment (2013)Comparative effect sizes in r…Clarifications on the application and interpretation of the test for excess significance and its extensions (2013)Clarifications on the applica…Primary study authors of significant studies are more likely to believe that a strong association exists in a heterogeneous meta-analysis compared with methodologists (2012)Primary study authors of sign…Perceived information gain from randomized trials correlates with publication in high–impact factor journals (2012)Perceived information gain fr…Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials (1995)Quantifying heterogeneity in a meta‐analysis (2002)Handbook of Meta-analysis in Ecology and Evolution (2013)Trial Sequential Analysis in systematic reviews with meta-analysis (2017)Statistical Methods for Meta-Analysis (1988)Operating Characteristics of a Rank Correlation Test for Publication Bias (1994)Systems to rate the strength of scientific evidence. (2002)The case of the misleading funnel plot (2006)The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey (2007)Empirical Evidence of Bias (1995)Assessing the quality of reports of randomized clinical trials: Is blinding necessary? 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(1986)The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration (2009)Conducting Meta-Analyses in R with the metafor Package (2010)Health Measurement Scales: A Practical Guide to Their Development and Use (1989)Bias in meta-analysis detected by a simple, graphical test (1997)Evaluating non-randomised intervention studies (2003)Chapter 9: Analysing Data and Undertaking Meta-Analyses (2008)Analysing data and undertaking meta‐analyses (2019)Meta-analysis of Observational Studies in Epidemiology A Proposal for Reporting (2000)The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials (2001)False-Positive Psychology (2011)Power failure: why small sample size undermines the reliability of neuroscience (2013)Estimating the reproducibility of psychological science (2015)The Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration (2001)Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration (2007)How Big Is “Big”? 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References

  • 1986Meta-analysis in clinical trials39,515 cited
  • 2005Why Most Published Research Findings Are False10,471 cited
  • 1999Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement4,828 cited
  • 2008Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study2,534 cited
  • 1997Quantitative Synthesis in Systematic Reviews2,515 cited
  • 2001Reported Methodologic Quality and Discrepancies between Large and Small Randomized Trials in Meta-Analyses2,285 cited
  • 2007Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis1,879 cited
  • 2008Why Most Discovered True Associations Are Inflated1,489 cited
  • 2005Contradicted and Initially Stronger Effects in Highly Cited Clinical Research1,465 cited
  • 1987Meta-Analyses of Randomized Controlled Trials1,253 cited
  • 1997Discrepancies between Meta-Analyses and Subsequent Large Randomized, Controlled Trials1,170 cited
  • 2008Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation1,146 cited
  • 2007Epidemiology and Reporting Characteristics of Systematic Reviews891 cited
  • 2008Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?

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834 cited
  • 1998Effect of the Statistical Significance of Results on the Time to Completion and Publication of Randomized Efficacy Trials631 cited
  • 2010Stopping Randomized Trials Early for Benefit and Estimation of Treatment Effects Systematic Review and Meta-regression Analysis613 cited
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    • 2016Poor agreement in significant findings between meta-analyses and subsequent large randomized trials in perioperative medicine58 cited
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    • 2018Statistical power of clinical trials increased while effect size remained stable: an empirical analysis of 136,212 clinical trials between 1975 and 201454 cited
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    • 2017Are Meta-Analyses a Form of Medical Fake News?38 cited