Suicidal Behaviors and the Tryptophan Hydroxylase Gene

Mocrane Abbar

80 citations0/0 files storedArchives of General Psychiatry

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Suicide and Self-Harm Studies Genetic Associations and Epidemiology Neurotransmitter Receptor Influence on Behavior

Abstract

BACKGROUND: To determine whether the tryptophan hydroxylase gene (ie, the gene that codes for the rate-limiting enzyme in the metabolic pathway of serotonin) may be a susceptibility factor for suicidal behavior. METHODS: Genotypic and allelic frequencies at a polymorphic Ava II restriction site were revealed with the use of the complementary DNA tryptophan hydroxylase probe C2-38 in 62 suicide attempters. The psychiatric characteristics of these suicide attempters were determined using the Schedule for Affective Disorders and Schizophrenia-Lifetime version with modification for the study of anxiety disorders, and these characteristics were compared with those in 52 healthy controls. RESULTS: No association between tryptophan hydroxylase and suicidal behavior was detected. CONCLUSION: The tryptophan hydroxylase gene was not a susceptibility factor for suicidal behaviors in the group of suicide attempters in this study.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 80 citations exist upstream.

References

19765-HIAA in the Cerebrospinal Fluid 1981Monoamine Metabolites in CSF and Suicidal Behavior 1989Cerebrospinal Fluid Monoamine Metabolites and Suicidal Behavior in Depressed Patients 1991Suicide in Twins 1985Suicide and Family Loading for Affective Disorders 1990Firearm Regulations and Rates of Suicide 1972RISE AND FALL OF SUICIDE RATES IN AUSTRALIA: RELATION TO SEDATIVE AVAILABILITY 1992Integration of Neurobiology and Psychopathology in a Unified Model of Suicidal Behavior

Cited by

2001Serotonergic Genes and Suicidality 2000Intermittent explosive disorder 2001Suicide in Teenagers 1997GENETIC STUDIES OF SUICIDAL BEHAVIOR 2017The Life Span Model of Suicide and Its Neurobiological Foundation

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.