Article2005

Suicide in 406 Mood-Disorder Patients With and Without Long-Term Medication: A 40 to 44 Years' Follow-Up

Jules Angst · Felix Angst · Regina Gerber-Werder · Alex Gamma

318 citations0/0 files storedArchives of Suicide Research

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Suicide and Self-Harm Studies Treatment of Major Depression Bipolar Disorder and Treatment

Abstract

There is no data on the variation in the suicide risk over lifetime and on the suicide-preventive effect of the long-term treatment of mood-disorder patients with antidepressants and neuroleptics. Our research focused on 186 unipolar (D), 60 bipolar II (Dm), 130 nuclear bipolar I (MD), and 30 preponderantly manic patients (M/Md); that were followed-up from 1963 to 2003. By 2003, 45 (11.1%) of the 406 patients had committed suicide. Suicide rates were highest among D patients (Standardized Mortality Ratio, SMR = 26.4), MD (SMR = 13.6), Dm (SMR = 10.6) and lowest among M/Md patients (SMR = 4.7). Prospectively, the suicide rate decreased over the 44 years' follow-up; Lithium, neuroleptics and antidepressants reduced suicides significantly. Long-term treatment also reduced overall mortality, and combined treatments proved more effective than mono-therapy.

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References

1972Diagnostic Criteria for Use in Psychiatric Research 1998Excess mortality of mental disorder 1974A Hundred Cases of Suicide: Clinical Aspects 2002Risk factors for suicide in China: a national case-control psychological autopsy study 2000Affective Disorders and Suicide Risk: A Reexamination 2002Suicide rates in China, 1995–99 1970Suicide and Primary Affective Disorders 1998Lifetime risk of suicide for affective disorder, alcoholism and schizophrenia

Cited by

2014Suicidal Behaviour in Mood Disorders—Who, When, and Why?2019Severity and Variability of Depression Symptoms Predicting Suicide Attempt in High-Risk Individuals 2010Reassessing the Long-term Risk of Suicide After a First Episode of Psychosis 2007Suicidal risks among 2826 Sardinian major affective disorder patients 2013Suicide and Attempted Suicide 2010Suicidality and Risk of Suicide—Definition, Drug Safety Concerns, and a Necessary Target for Drug Development

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