Article2008

Orbitofrontal Cortex Response to Angry Faces in Men With Histories of Suicide Attempts

Fabrice Jollant · Natalia Lawrence · Vincent Giampietro · Michael John Brammer · Miquel Angel Fullana · Dominique Drapier +2 more

262 citations0/0 files storedAmerican Journal of Psychiatry

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Suicide and Self-Harm Studies Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Neural and Behavioral Psychology Studies

Abstract

OBJECTIVE: The authors sought to elucidate the functional neural basis of the neurobiological abnormalities underlying the vulnerability to suicidal behavior. METHOD: Event-related functional MRI was used to measure neural activity in response to angry and happy versus neutral faces. Thirteen currently euthymic men with a history of major depressive disorder and suicidal behavior were compared with 14 currently euthymic men with a history of major depressive disorder but not of suicidal acts (affective comparison subjects) and 16 healthy male comparison subjects. RESULTS: Relative to affective comparison subjects, suicide attempters showed greater activity in the right lateral orbitofrontal cortex (Brodmann's area 47) and decreased activity in the right superior frontal gyrus (area 6) in response to prototypical angry versus neutral faces, greater activity in the right anterior cingulate gyrus (area 32 extending to area 10) to mild happy versus neutral faces, and greater activity in the right cerebellum to mild angry versus neutral faces. However, activation in these frontal regions did not differ between healthy individuals and either patient group. Relative to healthy comparison subjects, both patient groups showed reduced activity in the right cerebellum to neutral faces and to mild happy versus neutral faces. CONCLUSIONS: Suicide attempters were distinguished from nonsuicidal patients by responses to angry and happy faces that may suggest increased sensitivity to others' disapproval, higher propensity to act on negative emotions, and reduced attention to mildly positive stimuli. These patterns of neural activity and cognitive processes may represent vulnerability markers of suicidal behavior in men with a history of depression.

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References

1961An Inventory for Measuring Depression 1960A RATING SCALE FOR DEPRESSION 1998The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 1995Factor structure of the barratt impulsiveness scale 1999Toward a Clinical Model of Suicidal Behavior in Psychiatric Patients 2003Neurobiology of suicidal behaviour 2006Risk factors for suicidality in Europe: Results from the ESEMED study 2005Impaired Decision Making in Suicide Attempters

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2017Biomarkers of Suicide Attempt Behavior: Towards a Biological Model of Risk 2013Pain and suicidality: Insights from reward and addiction neuroscience 2011Structural and functional neuroimaging studies of the suicidal brain 2020A Brain-Centric Model of Suicidal Behavior 2017RETRACTED ARTICLE: Machine learning of neural representations of suicide and emotion concepts identifies suicidal youth

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