Suppression of Lymphocyte Stimulation Following Bereavement

Steven J. Schleifer

642 citations0/0 files storedJAMA

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Grief, Bereavement, and Mental Health Stress Responses and Cortisol Cancer, Stress, Anesthesia, and Immune Response

Abstract

In a prospective study of 15 spouses of women with advanced breast carcinoma, lymphocyte stimulation responses to phytohemagglutinin, concanavalin A, and pokeweed mitogen were significantly suppressed during the first two months following the death of a spouse compared with prebereavement levels. A highly significant suppression was seen as early as one month after bereavement. No differences were found in total lymphocyte or B- or T-cell numbers. An intermediate level of mitogen responsivity was found during the four- to 14-month period after bereavement. Suppressed immunity following the death of a spouse may be related to the increased morbidity and mortality associated with bereavement.

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2005Hostile Marital Interactions, Proinflammatory Cytokine Production, and Wound Healing 1987Marital quality, marital disruption, and immune function.2001The varieties of grief experience 1984Relationships as Regulators: A Psychobiologic Perspective on Bereavement*1988Marital discord and immunity in males.1987Impaired natural killer cell activity during bereavement 2003The effect of mirthful laughter on stress and natural killer cell activity.1998Coping with loss: Bereavement in adult life

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