Article2006

Augmentation of sertraline with prolonged exposure in the treatment of posttraumatic stress disorder

BARBARA OLASOV ROTHBAUM · Shawn P. Cahill · Edna B. Foa · Jonathan R. T. Davidson · Jill Compton · Kathryn M. Connor +2 more

131 citations0/0 files storedJournal of Traumatic Stress

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Posttraumatic Stress Disorder Research Psychoanalysis and Psychopathology Research Psychotherapy Techniques and Applications

Abstract

The present study was designed to determine whether augmenting sertraline with prolonged exposure (PE) would result in greater improvement than continuation with sertraline alone. Outpatient men and women with chronic PTSD completed 10 weeks of open label sertraline and then were randomly assigned to five additional weeks of sertraline alone (n = 31) or sertraline plus 10 sessions of twice-weekly PE (n = 34). Results indicated that sertraline led to a significant reduction in PTSD severity after 10 weeks but was associated with no further reductions after five more weeks. Participants who received PE showed further reduction in PTSD severity. This augmentation effect was observed only for participants who showed a partial response to medication.

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2018Doubly Randomized Preference Trial of Prolonged Exposure Versus Sertraline for Treatment of PTSD 2020A review of emerging therapeutic potential of psychedelic drugs in the treatment of psychiatric illnesses 2015Psychopharmacological Strategies in the Management of Posttraumatic Stress Disorder (PTSD): What Have We Learned?

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