Familial Tourette's Syndrome in a Large British Pedigree

Mary May Robertson · Alison L. Gourdie

94 citations0/0 files storedThe British Journal of Psychiatry

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Obsessive-Compulsive Spectrum Disorders Psychoanalysis and Psychopathology Research Stuttering Research and Treatment

Abstract

A British pedigree multiply affected by the Gilles de la Tourette syndrome and spanning six generations is described. Of 122 members identified, 85 were individually interviewed, and 50 were diagnosed as 'cases'. 'Cases' consisted of 29 with definite or probable Gilles de la Tourette syndrome, 17 with definite or probable chronic multiple tics, and four with definite or probable obsessive-compulsive behaviour. Only eight of the 50 'cases' had consulted a doctor for their symptoms. 'Cases' and 'non-cases' could be distinguished on the basis of echo-phenomena, obsessive-compulsive features, self-injurious behaviour, and the trait score of the Leyton Obsessional Inventory, but did not differ significantly on any other psychopathological variables. The pattern of inheritance of the Gilles de la Tourette syndrome in this pedigree is consistent with autosomal dominant transmission.

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References

1978A Diagnostic Interview 1973The detection of psychiatric illness by questionnaire 199426. Obsessions and Compulsions 1986Gilles de la Tourette's Syndrome and Obsessive-Compulsive Disorder 1966A Short Clinical Diagnostic Self-rating Scale for Psychoneurotic Patients 2021Gilles de la Tourette Syndrome 1986The Inheritance of Gilles de la Tourette's Syndrome and Associated Behaviors 1985A Twin Study of Tourette Syndrome

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2009Streptococcal infection, Tourette syndrome, and OCD 2002Obsessive compulsive behaviour and depressive symptoms in young people with Tourette syndrome 1997Personality disorder and psychopathology in Tourette's syndrome: A controlled study 1993Tourette syndrome: Associated symptoms and most disabling features

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