Neuropsychiatric Effects of Guanfacine in Children With Mild Tourette Syndrome: A Pilot Study

Dana D. Cummings · Harvey S. Singer · Madeline Krieger · Teresa Miller · E. Mark Mahone

119 citations0/0 files storedClinical Neuropharmacology

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Obsessive-Compulsive Spectrum Disorders Schizophrenia research and treatment Attention Deficit Hyperactivity Disorder

Abstract

The objective of this study was to evaluate the neuropsychiatric effects of the alpha-2a adrenergic agonist guanfacine in children with Tourette syndrome (TS). Twenty-four children with TS participated in a 4-week, double-blind, placebo-controlled study of guanfacine. Tic severity, neuropsychologic functioning, and parent ratings of behavior were evaluated pre- and post-treatment. The sample had mild tic severity and subtle neuropsychologic dysfunction pretreatment. Post-treatment, patients receiving guanfacine were rated by parents as significantly improved (compared to placebo) on one measure of executive function (parent-rated metacognition). Improvement on tic severity, performance-based neuropsychologic measures, and all other parent ratings were not significantly better than placebo. At a moderate dose and short-term treatment duration, guanfacine did not provide significant neuropsychiatric benefits in this group of children with mild TS.

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References

1996Improving the quality of reporting of randomized controlled trials. The CONSORT statement 1996Improving the Quality of Reporting of Randomized Controlled Trials 1989The Yale Global Tic Severity Scale: Initial Testing of a Clinician-Rated Scale of Tic Severity 1993Definitions and Classification of Tic Disorders 1986The Leyton Obsessional Inventory-Child Version 1995Guanfacine Treatment of Comorbid Attention-Deficit Hyperactivity Disorder and Tourette's Syndrome: Preliminary Clinical Experience 1998Disentangling the Overlap between Tourette's Disorder and ADHD 1995Executive function in children with Tourette Syndrome and/or Attention Deficit Hyperactivity Disorder

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