Metabolic Syndrome in People Suffering from Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis

Francesco Bartoli · Giuseppe Carrà · Cristina Crocamo · Daniele Carretta · Massimo Clerici

95 citations0/0 files storedMetabolic Syndrome and Related Disorders

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Posttraumatic Stress Disorder Research Diabetes, Cardiovascular Risks, and Lipoproteins Migration, Health and Trauma

Abstract

BACKGROUND: Previous reports showed a high prevalence of obesity, diabetes, hypertension, and dyslipidemia among people suffering from posttraumatic stress disorder (PTSD). However, there is a lack of reviews that systematically analyze the relationship between PTSD and metabolic syndrome. We conducted a systematic review and meta-analysis aimed at estimating the association between PTSD and metabolic syndrome. METHODS: We systematically searched PubMed, Embase, and Web of Science. We included observational studies assessing the prevalence of metabolic syndrome in a sample with PTSD and in a comparison group without PTSD. Data were analyzed using Review manager 5.1. Odds ratios (OR) with 95% confidence intervals were used as an association measure for pooled analysis, based on a random-effects model. RESULTS: Six articles were eligible according to the inclusion criteria, for an overall number of 528 individuals suffering from PTSD and 846 controls without PTSD. The pooled OR for metabolic syndrome for people with PTSD was 1.37 (1.03-1.82). Statistical heterogeneity between the included studies was low (I(2)=22%). CONCLUSIONS: Despite some limitations, the findings of this systematic review and meta-analysis confirmed our hypothesis that individuals suffering from PTSD have a greater risk of metabolic syndrome. The potential role of unknown factors or mediators that might clarify the nature of this association needs further research.

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References

2009Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement 2009Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement 2001Clinician-administered PTSD scale: A review of the first ten years of research 1998Meta-analysis Spurious precision? Meta-analysis of observational studies 2008A Prospective Study of PTSD and Early-Age Heart Disease Mortality Among Vietnam Veterans: Implications for Surveillance and Prevention 2005Posttraumatic Stress Disorder and Mortality Among U.S. Army Veterans 30 Years After Military Service 2009The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans 2010Posttraumatic Stress Disorder, Cardiovascular, and Metabolic Disease: A Review of the Evidence

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