Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration

George A. Ricaurte · Louis E. DeLanney · Ian Irwin · J. William Langston

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Psychedelics and Drug Studies Neurotransmitter Receptor Influence on Behavior Forensic Toxicology and Drug Analysis

Abstract

This study compared the toxic effects of oral versus subcutaneous and single versus multiple doses of 3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in non-human primates. Orally administered MDMA was approximately one-half as effective as subcutaneously administered drug. Multiple doses were more effective than single doses, but a single 5 mg/kg dose of MDMA given orally still produced a long-lasting depletion of serotonin in the monkey brain. These results indicate that when MDMA is given to monkeys in a manner similar to that employed by humans, it exerts toxic effects on central serotonergic neurons. This suggests that humans using MDMA may be at risk for incurring central serotonergic neuronal damage.

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References

1987Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine.1987Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain.1985Hallucinogenic Amphetamine Selectively Destroys Brain Serotonin Nerve Terminals 1988(+/-)3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates

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