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Impact of Sleep Quality on Amygdala Reactivity, Negative Affect, and Perceived Stress

Aric A. Prather · Ryan Bogdan · Ahmad R. Hariri

137 citations0/0 files storedPsychosomatic Medicine

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Abstract

OBJECTIVE: Research demonstrates a negative impact of sleep disturbance on mood and affect; however, the biological mechanisms mediating these links are poorly understood. Amygdala reactivity to negative stimuli has emerged as one potential pathway. Here, we investigate the influence of self-reported sleep quality on associations between threat-related amygdala reactivity and measures of negative affect and perceived stress. METHODS: Analyses on data from 299 participants (125 men, 50.5% white, mean [standard deviation] age = 19.6 [1.3] years) who completed the Duke Neurogenetics Study were conducted. Participants completed several self-report measures of negative affect and perceived stress. Threat-related (i.e., angry and fearful facial expressions) amygdala reactivity was assayed using blood oxygen level-dependent functional magnetic resonance imaging. Global sleep quality was assessed using the Pittsburgh Sleep Quality Index. RESULTS: Amygdala reactivity to fearful facial expressions predicted greater depressive symptoms and higher perceived stress in poor (β values = 0.18-1.86, p values < .05) but not good sleepers (β values = -0.13 to -0.01, p values > .05). In sex-specific analyses, men reporting poorer global sleep quality showed a significant association between amygdala reactivity and levels of depression and perceived stress (β values = 0.29-0.44, p values < .05). In contrast, no significant associations were observed in men reporting good global sleep quality or in women, irrespective of sleep quality. CONCLUSIONS: This study provides novel evidence that self-reported sleep quality moderates the relationships between amygdala reactivity, negative affect, and perceived stress, particularly among men.

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References

1977The CES-D Scale 1989The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research 1983A Global Measure of Perceived Stress 2011Insomnia as a predictor of depression: A meta-analytic evaluation of longitudinal epidemiological studies 2011Gender differences in anxiety disorders: Prevalence, course of illness, comorbidity and burden of illness 1977Sex Differences and the Epidemiology of Depression 1996Sleep disturbance and psychiatric disorders: A longitudinal epidemiological study of young Adults 2009Quantity and Quality of Sleep and Incidence of Type 2 Diabetes

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