Reorganization of the Connectivity of Cortical Field DZ in Congenitally Deaf Cat

Pascal Barone · Ludovic Lacassagne · Andrej Kral

111 citations0/0 files storedPLoS ONE

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Multisensory perception and integration Neuroscience and Music Perception Tactile and Sensory Interactions

Abstract

Psychophysics and brain imaging studies in deaf patients have revealed a functional crossmodal reorganization that affects the remaining sensory modalities. Similarly, the congenital deaf cat (CDC) shows supra-normal visual skills that are supported by specific auditory fields (DZ-dorsal zone and P-posterior auditory cortex) but not the primary auditory cortex (A1). To assess the functional reorganization observed in deafness we analyzed the connectivity pattern of the auditory cortex by means of injections of anatomical tracers in DZ and A1 in both congenital deaf and normally hearing cats. A quantitative analysis of the distribution of the projecting neurons revealed the presence of non-auditory inputs to both A1 and DZ of the CDC which were not observed in the hearing cats. Firstly, some visual (areas 19/20) and somatosensory (SIV) areas were projecting toward DZ of the CDC but not in the control. Secondly, A1 of the deaf cat received a weak projection from the visual lateral posterior nuclei (LP). Most of these abnormal projections to A1 and DZ represent only a small fraction of the normal inputs to these areas. In addition, most of the afferents to DZ and A1 appeared normal in terms of areal specificity and strength of projection, with preserved but smeared nucleotopic gradient of A1 in CDCs. In conclusion, while the abnormal projections revealed in the CDC can participate in the crossmodal compensatory mechanisms, the observation of a limited reorganization of the connectivity pattern of the CDC implies that functional reorganization in congenital deafness is further supported also by normal cortico-cortical connectivity.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 111 citations exist upstream.

References

2004The Handbook of Multisensory Processing 1987Attention to central and peripheral visual space in a movement detection task: an event-related potential and behavioral study. II. Congenitally deaf adults 2010Cross-modal plasticity in specific auditory cortices underlies visual compensations in the deaf 2006Do deaf individuals see better?1988Experimentally Induced Visual Projections into Auditory Thalamus and Cortex 2006Physiological and Anatomical Evidence for Multisensory Interactions in Auditory Cortex 2003Visual stimuli activate auditory cortex in deaf subjects: evidence from MEG 2009Multisensory anatomical pathways

Cited by

2017Task Selectivity as a Comprehensive Principle for Brain Organization 2016Cross-Modal Plasticity in Higher-Order Auditory Cortex of Congenitally Deaf Cats Does Not Limit Auditory Responsiveness to Cochlear Implants 2013Cross‐modal reorganization of cortical afferents to dorsal auditory cortex following early‐ and late‐onset deafness 2017Variations in phonological working memory: Linking early language experiences and language learning outcomes

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.