Association between Adverse Childhood Experiences and Diagnosis of Cancer

Monique J. Brown · Leroy R. Thacker · Steven A. Cohen

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Child Abuse and Trauma Global Cancer Incidence and Screening Cancer Risks and Factors

Abstract

OBJECTIVE: Adverse childhood experiences (ACEs) are linked to multiple adverse health outcomes. This study examined the association between ACEs and cancer diagnosis. METHODS: Data from the 2010 Behavioral Risk Factor Surveillance System (BRFSS) survey were used. The BRFSS is the largest ongoing telephone health survey, conducted in all US states, the District of Columbia, Puerto Rico, Guam and the U.S. Virgin Islands, and provides data on a variety of health issues among the non-institutionalized adult population. Principal component analysis (PCA) was used to derive components for ACEs. Multivariable logistic regression models were used to provide adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between ACE components and overall, childhood and adulthood cancer, adjusting for confounders such as age, gender, race/ethnicity, income, educational status, marital status, and insurance status. RESULTS: Approximately 62% of respondents reported being exposed to ACEs and about one in ten respondents reported ever having been diagnosed with cancer. Component 1, which had the sexual abuse variables with the highest weights, was significantly associated with adulthood cancer (adjusted OR: 1.21; 95% CI: 1.03-1.43). CONCLUSION: The association between ACEs and adulthood cancer may be attributable to disease progression through association of ACEs with risk factors for other chronic diseases. More research should focus on the impact of sexual abuse ACEs and adverse health outcomes.

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References

1998Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults 2004Adverse childhood experiences and the risk of depressive disorders in adulthood 2004The interrelatedness of multiple forms of childhood abuse, neglect, and household dysfunction 2004Insights Into Causal Pathways for Ischemic Heart Disease 2010Building a Framework for Global Surveillance of the Public Health Implications of Adverse Childhood Experiences 2004Assessing the reliability of retrospective reports of adverse childhood experiences among adult HMO members attending a primary care clinic 2003The relationship of exposure to childhood sexual abuse to other forms of abuse, neglect, and household dysfunction during childhood 2008Adverse Childhood Experiences and Chronic Obstructive Pulmonary Disease in Adults

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