Neurobiology of PTSD: A Review of Neuroimaging Findings

Abstract

Neuroimaging serves as an effec-tive way to investigate the neu-rocircuitry involved in the de-velopment of posttraumatic stress disorder (PTSD).1-3 A number of models describing functional neuroanatomy of PTSD symp-tom development emerged over the past decade, inspired by both basic animal re-search and an increasing number of human neuroimaging studies. These models have traditionally conceptualized PTSD as a state of heightened responsivity to threat-ening stimuli and later as a state of insuf-fi cient inhibitory control over-exaggerated threat-sensitivity. They emphasize the cen-trality of threat-related processing in the pathophysiology of PTSD and therefore

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