Does prevalence of transfusion‐transmissible viral infection reflect corresponding incidence in United States blood donors?

Baoguang Wang · George B. Schreiber · Steven H Kleinman · David J. Wright · Edward L. Murphy · Michael Paul Busch

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Blood donation and transfusion practices HIV/AIDS Research and Interventions Blood transfusion and management

Abstract

BACKGROUND: Calculation of viral residual risk is dependent on estimating incidence, which is not easily obtainable by most blood centers. Prevalence, however, is readily available. Understanding whether prevalence reflects corresponding incidence may help blood centers monitor disease risks. STUDY DESIGN AND METHODS: With data on 12 million allogeneic donations, prevalence and incidence of transfusion-transmitted viral infections (TTVIs) were calculated. Relationships between prevalence (in total, first-time, and repeat donations) and incidence were analyzed for human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) relative to temporal and donor demographic stratifications, respectively. RESULTS: Overall prevalence of HIV, HBV, and HCV did not consistently reflect corresponding incidence. The relationship between prevalence and incidence varied with time and donors' age and was virus-specific. CONCLUSION: Incidence of TTVIs cannot be easily predicted from overall prevalence. Accurate assessment of TTVI risk necessitates knowledge about donation histories and person-years at risk. Establishing comprehensive frameworks for monitoring blood donations and infectious disease markers remains a key to monitoring blood safety.

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References

1996The Risk of Transfusion-Transmitted Viral Infections 2002Current prevalence and incidence of infectious disease markers and estimated window‐period risk in the American Red Cross blood donor population 2004Detection of HIV-1 and HCV Infections among Antibody-Negative Blood Donors by Nucleic Acid–Amplification Testing 2005A new strategy for estimating risks of transfusion‐transmitted viral infections based on rates of detection of recently infected donors 1995Estimated Risk of Transmission of the Human Immunodeficiency Virus by Screened Blood in the United States 2003Current and Emerging Infectious Risks of Blood Transfusions 2000Trends in Incidence and Prevalence of Major Transfusion-Transmissible Viral Infections in US Blood Donors, 1991 to 1996 1997Estimates of Infectious Disease Risk Factors in US Blood Donors

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