DETERMINATION OF MONOAMINE AND MONOAMINE METABOLITES IN THE HUMAN BRAIN: POST MORTEM STUDIES IN A GROUP OF SUICIDES AND IN A CONTROL GROUP

Jan Beskow · C. G. Gottfries · B. E. Roos · Bengt G. Winblad

225 citations0/0 files storedActa Psychiatrica Scandinavica

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Suicide and Self-Harm Studies Neurotransmitter Receptor Influence on Behavior Tryptophan and brain disorders

Abstract

Different nuclei and regions of the brain from patients who had committed suicide and from controls were analysed for their content of monoamine and monoamine metabolites. There was a post mortem breakdown of 5-hydroxyindoleacetic acid (5-HIAA) which could be correlated to the time elapsed between the occurrence of death and autopsy. Homovanillic acid (HVA) and the monoamines did not decrease post mortem during the time observed (6-148 hours). There was no significant correlation between age and chemical variables in this investigation. There were no significant group differences between suicides and controls concerning dopamine, noradrenaline, 5-hydroxytryptamine, and HVA, 5-HIAA levels were significantly lower in the suicide group in six out of eight parts of the brain investigated. It was, however, also demonstrated that there was a longer time elapse between the occurrence of death and autopsy in the suicide group. The suicides came on average 48 hours later to autopsy than the controls. As there was a post mortem decrease of 5-HIAA, this time variable had to be kept constant when group differences were analysed. When the influence of this time variable was eliminated there were no longer any differences between suicides and controls. According to this investigation, there seem to be no differences in levels of monoamines and their metabolites between suicides and controls.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 225 citations exist upstream.

References

1968NORADRENALINE, 5-HYDROXYTRYPTAMINE, AND 5-HYDROXYINDOLEACETIC ACID IN HINDBRAINS OF SUICIDAL PATIENTS 19695-HYDROXYTRYPTAMINE, NORADRENALINE, AND DOPAMINE IN BRAINSTEM, HYPOTHALAMUS, AND CAUDATE NUCLEUS OF CONTROLS AND OF PATIENTS COMMITTING SUICIDE BY COAL-GAS POISONING

Cited by

1988Brain 5-HT2 receptor binding sites in depressed suicide victims 1984CSF 5-hydroxyindoleacetic acid levels in suicidal schizophrenic patients 1989Evidence for the 5-HT Hypothesis of Suicide A Review of Post-mortem Studies 1996Attempted Suicide Characteristics and Cerebrospinal Fluid Amine Metabolites in Depressed Inpatients 1990Brain 5-HT1 binding sites in depressed suicides 1991Serotonergic measures in suicide brain: 5-HT1A binding sites in frontal cortex of suicide victims 2008Stress, Genes and the Biology of Suicidal Behavior 2003Reactive aggression and suicide

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.