Blood Donations and Risk of Coronary Heart Disease in Men

Alberto Ascherio · Eric B. Rimm · Edward L. Giovannucci · Walter Churchill Willett · Meir J. Stampfer

191 citations0/0 files storedCirculation

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Blood donation and transfusion practices Iron Metabolism and Disorders Blood transfusion and management

Abstract

BACKGROUND: In experimental animals, iron overload appears to promote atherosclerosis and ischemic myocardial damage, but the results of epidemiological studies that relate iron stores to risk of coronary heart disease (CHD) have been inconsistent. METHODS AND RESULTS: We prospectively studied blood donations, which effectively reduce body iron stores, in relation to the risk of CHD among participants in the Health Professionals Follow-up Study. The lifetime history of blood donation was assessed with a questionnaire in 1992. The 38 244 men who were free of diagnosed cardiovascular disease at that time were included in the analyses. During 4 years of follow-up, we documented 328 nonfatal myocardial infarctions and 131 coronary deaths. Although the number of lifetime blood donations was strongly associated with lower plasma ferritin levels in a subsample, the blood donation was not associated with risk of myocardial infarction or fatal CHD. The age-adjusted relative risk (RR) of myocardial infarction for men in the highest category of blood donations (>/=30) compared with never donors was 1.2 (95% CI 0. 8 to 1.8), and this RR was not materially changed after adjustment for several coronary risk factors. No significant associations were found between blood donation and the risk of myocardial infarction in analyses restricted to men with hypercholesterolemia or those who never used antioxidant supplements or aspirin. CONCLUSIONS: The study results do not support the hypothesis that reduced body iron stores lower CHD risk.

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References

1968Cardiovascular Survey Methods.1990NATIONAL SOURCES OF VITAL STATUS INFORMATION: EXTENT OF COVERAGE AND POSSIBLE SELECTIVITY IN REPORTING 1998Donation of Blood Is Associated with Reduced Risk of Myocardial Infarction: The Kuopio Ischaemic Heart Disease Risk Factor Study

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2011Healthy donor effect: its magnitude in health research among blood donors 2002A historical cohort study of the effect of lowering body iron through blood donation on incident cardiac events 2005Iron Stores and Vascular Function in Voluntary Blood Donors 2008Donation Frequency, Iron Loss, and Risk of Cancer Among Blood Donors 2011The healthy donor effect: a matter of selection bias and confounding 2010Cardiovascular and demographic characteristics in whole blood and plasma donors: results from the Donor InSight study 2009Selection Criteria to Protect the Blood Donor in North America and Europe: Past (Dogma), Present (Evidence), and Future (Hemovigilance)2008Evidence‐based criteria for the care and selection of blood donors, with some comments on the relationship to blood supply, and emphasis on the management of donation‐induced iron depletion

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