Article1986

Gilles de la Tourette's Syndrome and Attention Deficit Disorder With Hyperactivity

161 citations0/0 files storedArchives of General Psychiatry

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Obsessive-Compulsive Spectrum Disorders Psychoanalysis and Psychopathology Research Attention Deficit Hyperactivity Disorder

Abstract

Results of a family study of Gilles de la Tourette's syndrome (TS) suggest that TS and attention deficit disorder (ADD) with hyperactivity are genetically separate disorders transmitted independently in families at risk. Although the rate of TS among the relatives of the two proband groups was virtually the same (10.3% vs 11.1%), the rate of ADD among the relatives of probands with TS and ADD with hyperactivity was approximately eight times higher than the rate of ADD among the relatives of the probands with TS only. In those families where the proband had both TS and ADD, the two traits segregated independently. Therefore, there is no evidence to suggest that the two disorders are genetically related.

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References

1982Best Estimate of Lifetime Psychiatric Diagnosis 2021Gilles de la Tourette Syndrome 1982Stimulant Medications Precipitate Tourette's Syndrome 1980Gilles de la tourette syndrome: Clinical and family study of 50 cases 1984Tourette's Syndrome and Attention Deficit Disorder with Hyper activity: Are They Genetically Related?

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1991A high risk study of young children of parents with panic disorder and agoraphobia with and without comorbid major depression 1995A Case-Control Family History Study of Depression in Adolescents 2006Attention deficit hyperactivity disorder, tics and Tourette’s syndrome: the relationship and treatment implications. A commentary 1990Segregation and Linkage Analyses of Tourette's Syndrome and Related Disorders 1987Motor, Behavioral and Pharmacologic Findings in Tourette's Syndrome 1993Nortriptyline Treatment of Children with Attention-deficit Hyperactivity Disorder and Tic Disorder or Tourette's Syndrome 2002A Factor Analysis of Tic Symptoms in Gilles de la Tourette’s Syndrome 1991Clinical and genetic relationships between autism‐pervasive developmental disorder and Tourette syndrome: A study of 19 cases

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