Trends in transfusion‐transmissible infections among A ustralian blood donors from 2005 to 2010

Tarana T.A. Lucky · Clive R. Seed · A. J. Keller · June Lee · Ann McDonald · S. Ismay +2 more

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Blood donation and transfusion practices HIV/AIDS Research and Interventions Blood transfusion and management

Abstract

BACKGROUND: Routine monitoring of trends in transfusion-transmissible infections (TTIs) is essential to maintaining and improving transfusion safety. Although periodic studies have been published there is no comprehensive trend analysis for TTIs in Australian donors. This study determined recent trends in TTIs for which testing is conducted in Australia and described key attributes of infected blood donors. STUDY DESIGN AND METHODS: This is a retrospective analysis using data on donation testing for TTIs (2005-2010) from the national blood service donor database and data on postdonation interviews with TTI-positive donors (2008-2010) from a risk factor database incorporating responses to standardized interview questions. The study measured the prevalence and incidence of TTIs in Australia and assessed their time trends. Multivariate analysis of time trends was conducted using Poisson regression models. RESULTS: Overall, the prevalence and incidence of TTIs in 2005 to 2010 remained low and steady. The prevalence of hepatitis C virus decreased (rate ratio [RR], 0.93; 95% confidence interval [CI], 0.89-0.97) and the prevalence of active syphilis increased (RR, 1.51; 95% CI, 1.15-1.99) significantly during the study period. Prevalence of TTIs among Australian blood donors was substantially lower than that in the general population and no unique risk factors were identified in test-positive blood donors when compared with the general population. CONCLUSION: Both the prevalence and the incidence of TTIs in Australian blood donors remained low, with a steady or declining trend for most infections except active syphilis. The lower prevalence of TTIs in blood donors compared with the general population reflects the effectiveness of donor education and donor selection measures in Australia.

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2005A new strategy for estimating risks of transfusion‐transmitted viral infections based on rates of detection of recently infected donors 2010Prevalence, incidence, and residual risk of human immunodeficiency virus and hepatitis C virus infections among United States blood donors since the introduction of nucleic acid testing 2007Current incidence and estimated residual risk of transfusion‐transmitted infections in donations made to Canadian Blood Services 2003Incidence and estimated rates of residual risk for HIV, hepatitis C, hepatitis B and human T-cell lymphotropic viruses in blood donors in Canada, 1990-2000.2006Assessing the impact of HBV NAT on window period reduction and residual risk 2005Residual risk of transfusion transmitted human immunodeficiency virus, hepatitis B virus, hepatitis C virus and human T lymphotrophic virus 2007Reducing the risk of transfusion‐transmissible viral infection through blood donor selection: the Australian experience 2000 through 2006 2011Views and experiences of men who have sex with men on the ban on blood donation: a cross sectional survey with qualitative interviews

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