DECIPHERING THE GENETIC BASIS OF SPEECH AND LANGUAGE DISORDERS

Simon E. Fisher · Cecilia S. L. Lai · Anthony P. Monaco

170 citations0/0 files storedAnnual Review of Neuroscience

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Language Development and Disorders Neurobiology of Language and Bilingualism Genetics and Neurodevelopmental Disorders

Abstract

A significant number of individuals have unexplained difficulties with acquiring normal speech and language, despite adequate intelligence and environmental stimulation. Although developmental disorders of speech and language are heritable, the genetic basis is likely to involve several, possibly many, different risk factors. Investigations of a unique three-generation family showing monogenic inheritance of speech and language deficits led to the isolation of the first such gene on chromosome 7, which encodes a transcription factor known as FOXP2. Disruption of this gene causes a rare severe speech and language disorder but does not appear to be involved in more common forms of language impairment. Recent genome-wide scans have identified at least four chromosomal regions that may harbor genes influencing the latter, on chromosomes 2, 13, 16, and 19. The molecular genetic approach has potential for dissecting neurological pathways underlying speech and language disorders, but such investigations are only just beginning.

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References

2003Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)1994On The Language Instinct 2002Molecular evolution of FOXP2, a gene involved in speech and language 1994The children's test of nonword repetition: A test of phonological working memory 1973Defects of Non-Verbal Auditory Perception in Children with Developmental Aphasia 1991Familial aggregation of a developmental language disorder 1998Localisation of a gene implicated in a severe speech and language disorder 1995Praxic and nonverbal cognitive deficits in a large family with a genetically transmitted speech and language disorder.

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