Association of the rs3743205 variant of DYX1C1 with dyslexia in Chinese children

Cadmon K.P. Lim · Connie Suk‐Han Ho · Crystal Hin Ning Chou · Mary Miu Yee Waye

47 citations0/0 files storedBehavioral and Brain Functions

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Reading and Literacy Development Language Development and Disorders Genetic Associations and Epidemiology

Abstract

BACKGROUND: Dyslexia is a learning disability that is characterized by difficulties in the acquisition of reading and spelling skills independent of intelligence, motivation or schooling. Studies of western populations have suggested that DYX1C1 is a candidate gene for dyslexia. In view of the different languages used in Caucasian and Chinese populations, it is therefore worthwhile to investigate whether there is an association of DYX1C1 in Chinese children with dyslexia. METHOD AND RESULTS: Eight single nucleotide polymorphisms (SNPs) were genotyped from three hundred and ninety three individuals from 131 Chinese families with two which have been reported in the literature and six tag SNPs at DYX1C1. Analysis for allelic and haplotypic associations was performed with the UNPHASED program and multiple testing was corrected using false discovery rates. We replicated the previously reported association of rs3743205 in Chinese children with dyslexia (p(corrected) = 0.0072). This SNP was also associated with rapid naming, phonological memory and orthographic skills in quantitative trait analysis. CONCLUSION: Our findings suggest that DYX1C1 is associated with dyslexia in people of Chinese ethnicity in Hong Kong.

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References

1998Dyslexia 2004Biological abnormality of impaired reading is constrained by culture 2005DCDC2 is associated with reading disability and modulates neuronal development in the brain 2003A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain 2003Cognitive profiling and preliminary subtyping in Chinese developmental dyslexia 2008A structural–functional basis for dyslexia in the cortex of Chinese readers 2006The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319 , a novel gene involved in neuronal migration 1997Learning to Read Chinese Beyond the Logographic Phase

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2012Molecular Networks of DYX1C1 Gene Show Connection to Neuronal Migration Genes and Cytoskeletal Proteins 2017Visual motion and rapid auditory processing are solid endophenotypes of developmental dyslexia 2014Gene–environment interaction on neural mechanisms of orthographic processing in Chinese children

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