Reviewbronze1996

Determinants of longevity: genetic, environmental and medical factors

204 citations0/0 files storedJournal of Internal Medicine

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Insurance, Mortality, Demography, Risk Management Health disparities and outcomes Genetics, Aging, and Longevity in Model Organisms

Abstract

This review focuses on the determinants of longevity in the industrialized world, with emphasis on results from recently established data bases. Strong evidence is now available that demonstrates that in developed countries the maximum lifespan as well as the mean lifespan have increased substantially over the past century. There is no evidence of a genetically determined lifespan of around 85 years. On the contrary, the biggest absolute improvement in survival in recent decades has occurred amongst 80+ year-olds. Approximately one-quarter of the variation in lifespan in developed countries can be attributed to genetic factors. The influence of both genetic and environmental factors on longevity can potentially be modified by medical treatment, behavioural changes and environmental improvements.

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References

1987Human Aging: Usual and Successful 1980Aging, Natural Death, and the Compression of Morbidity 1985Heterogeneity's Ruses: Some Surprising Effects of Selection on Population Dynamics 1982Changing Concepts of Morbidity and Mortality in the Elderly Population 2005The Compression of Morbidity 1994Reductions in Mortality at Advanced Ages: Several Decades of Evidence from 27 Countries 1995Survival after the Age of 80 in the United States, Sweden, France, England, and Japan 1986How Change in Age-specific Mortality Affects Life Expectancy

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