Out of sight but not out of mind: how to search for unpublished clinical trial evidence

A.-W. Chan

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Meta-analysis and systematic reviews Academic Publishing and Open Access Pharmaceutical industry and healthcare

Abstract

A key challenge in conducting systematic reviews is to identify the existence and results of unpublished trials, and unreported methods and outcomes within published trials. An-Wen Chan provides guidance for reviewers on adopting a comprehensive strategy to search beyond the published literature

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References

2011The Cochrane Collaboration's tool for assessing risk of bias in randomised trials 2008Cochrane Handbook for Systematic Reviews of Interventions 2004Empirical Evidence for Selective Reporting of Outcomes in Randomized Trials 2008Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias 2010Dissemination and publication of research findings: an updated review of related biases 2005Identifying outcome reporting bias in randomised trials on PubMed: review of publications and survey of authors 2010The quality of reports of randomised trials in 2000 and 2006: comparative study of articles indexed in PubMed 2003Implications of the Tobacco Industry Documents for Public Health and Policy

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2016How do authors of systematic reviews deal with research malpractice and misconduct in original studies? A cross-sectional analysis of systematic reviews and survey of their authors 2023A Guide for Accounting Researchers to Conduct and Report Systematic Literature Reviews 2017Search for unpublished data by systematic reviewers: an audit 2025Reporting summary results in clinical trial registries: updated guidance from WHO

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