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This chapter introduces Mobile Healthcare Systems (MHS) and employs some theories to explore the behavioral intention of Smartphone users in Penang, Malaysia to use MHS. A survey was conducted in the form of questionnaire to Smartphone users in Penang, Malaysia for the duration of three weeks starting in September 2013. A total number of 123 valid surveys out of 150 were returned, which is equivalent to a response rate of 82%. The authors use Partial Least Squares (PLS) for analyzing the proposed measurement model. The factors that are tested are self-efficacy, anxiety, effort expectancy, performance expectancy, attitude, and behavioral intention to use. The results indicate which factors have a significant effect on Smartphone users' behavioral intention and which factors are not significant. The results assist in assessing whether MHS is highly demanded by users or not, and will assist in development of the system in the future.
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